Large registry-based analysis of genetic predisposition to tuberculosis identifies genetic risk factors at HLA.

Hum Mol Genet · 2023 · PMC9838093 · PMID 36018815

Europe PMC DOI

hedged sentences

0.0910

closest p · 1.8× alpha

0.1600

boldest claim

The sentences

close to significanceP = 0.091so close (0.05 < p ≤ 0.1)

In our current study, the homozygosity of TYK2 P1104A variant was close to significance although we were not able to replicate it in the current study ( P = 0.091).

also in 2,130 other papers

did not reach statistical significanceP = 0.16not close (p > 0.1)

Furthermore, the effects were in the same direction in the UKB, but did not reach statistical significance (rs9391858: P = 0.16, beta [SE] = −0.05 [0.03], and rs33915496: P = 0.35, beta [SE] = 0.02 [0.03]).

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.