Of note, even in the group resembling those for whom dabrafenib/trametinib is purported to do best (those with performance status 0, normal LDH, and lower stage, perhaps a surrogate for < 3 disease sites), starting with nivolumab/ipilimumab showed a trend for improved OS.
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Combination Dabrafenib and Trametinib Versus Combination Nivolumab and Ipilimumab for Patients With Advanced <i>BRAF</i>-Mutant Melanoma: The DREAMseq Trial-ECOG-ACRIN EA6134.
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