Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice.

Sci Rep · 2023 · PMC9842734 · PMID 36646781

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.1000

boldest claim

The sentences

marginally significantp = .06so close (0.05 < p ≤ 0.1)

A significant two-way stage x sex interaction influencing infusions [F (1, 28) = 4.56, p < .05] and a marginally significant three-way strain x lever x sex interaction influencing lever pressing [F (1, 28) = 3.79, p = .06] indicated that escalation was sex dependent and that lever pressing varied as a function of the relationship between strain, lever, and sex.

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did not reach statistical significancep = .10so close (0.05 < p ≤ 0.1)

The interaction was further driven by an increase in infusion attempts by females following acute restraint stress, although the increase in females did not reach statistical significance ( p = .10).

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