Enrichment of titin-truncating variants in exon 327 in dilated cardiomyopathy and its relevance to reduced nonsense-mediated mRNA decay efficiency.

Front Genet · 2022 · PMC9845391 · PMID 36685919

Europe PMC DOI

hedged sentence

0.0501

closest p · 1.0× alpha

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boldest claim

The sentences

did not reach statistical significancep = .0501so close (0.05 < p ≤ 0.1)

Although the difference between exon 327 TTNtv and other DCM-related TTNtv did not reach statistical significance ( p = .0501), the low AI deviation values generally observed for DCM-related TTNtvs demonstrated the importance of NMD evasion in the pathogenesis of TTNtv-related DCM.

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