Separate and combined effects of advanced age and obesity on mammary adipose inflammation, immunosuppression and tumor progression in mouse models of triple negative breast cancer.

Differences in tumor mass and metastases between aged DIO and young DIO did not reach statistical significance ( Figures 5F–H ) . 3.7 Obesity combined with advanced age heightens inflammatory perturbations and tumor immune suppression more than advanced age alone in an E0771 cell transplant model of TNBC Given that advanced age combined with obesity increased transplanted E0771 tumor burden in aged DIO mice to a greater extent than either advanced age or DIO alone, we assessed whether levels of tumor-promoting serum cytokines and/or systemic inflammation were increased in aged DIO mice, relative to all other groups.

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