Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis.

Cardiovasc Res · 2023 · PMC9847560 · PMID 35325057

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38 In addition, plaque oxidant damage (8OH-dG) showed a trend to increase (data not shown), and quantitative RT–PCR of ferumoxtran-treated and control foam cells revealed a strong up-regulation of oxidative stress-related p22phox (also known as neutrophil cytochrome b light chain), and the pro-apoptotic BCL2 associated X, apoptosis regulator (BAX), and X-linked inhibitor of apoptosis genes ( Figure 3C ).

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