Biological Functions of Selenoprotein Glutathione Peroxidases (GPXs) and their Expression in Osteoarthritis.

GPX4 expression showed a trend of increase in the OA group compared with the control group (95% CI=−0.17–0.39, P >0.05) ( Figure 6D ).

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The results of Meta-analysis showed that GPX1 expression was significantly increased in the OA group than that in the healthy controls (95% CI=0.01–1.43, P ≤0.05) ( Figure 6A ). Similarly, the selected datasets including GPX2 expression were heterogeneous (I 2 =79%, P <0.05), and the random effects model was used for Meta-analysis, which showed a decreasing trend of GPX2 expression in the OA group compared with the control group (95% CI=−1.48–0.02, P >0.05) ( Figure 6B ).

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