LD lookup variants were chosen using the following criteria: (1) they were less than 1,500 kb away from the lead variant; (2) they had a P < 0.01; (3) and their LD squared Pearson’s correlation with the lead variant was higher than a dynamic LD threshold based on the P value of the lead variant so that the expected P value of the linked variant would be nominally significant ( r 2 = 5/inverse chi-squared survival function ( P value)).
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FinnGen provides genetic insights from a well-phenotyped isolated population.
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