The Programmed Death-1 Signaling Axis Modulates Inflammation and LV Structure/Function in a Stress-Induced Cardiomyopathy Model.

Consistent with the increase in ISO-induced myocyte injury in WT mice treated with an anti-PD-L1 Ab, there was also a significant trend (P = 0.079) toward increase in heart weight-to-tibia length on day 2 in these mice relative to isotype control-treated mice, and a significantly greater increase in heart weight-to-tibia length at day 7 in the PD1 −/− mice relative to WT mice (P = 0.028) ( Supplemental Figure S13A ).

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