Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies.

Autophagy · 2023 · PMC9851246 · PMID 35867714

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0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

very close to statistical significancep = 0.052so close (0.05 < p ≤ 0.1)

Blockade of PPP3/calcineurin in cultured neurons by treatment with cyclosporine A (CsA) did not prevent TFEB dephosphorylation during gLTP (Figure S4A, quantification in B, a trend very close to statistical significance, p = 0.052), indicating that the main source of TFEB dephosphorylation might be MTOR inhibition.

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did not reach statistical significanceno p-value reported

However, we detected a decrease in TFEB phosphorylation at Ser 142 of 69 ± 3% and 75 ± 4% in Tg-S and WT-S, respectively, compared to Tg-NS samples (comparison with WT-NS did not reach statistical significance due to high variability in TFEB levels) indicating that TFEB is activated upon DBS ( Figure 4C , upper panel, quantification in E).

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