Identification and experimental validation of key m6A modification regulators as potential biomarkers of osteoporosis.

Because the sample size was limited (although still among the largest of such studies in this field), we used a p -value <0.05 as the threshold for nominally significant differential expression. 2.3 Analysis of the characteristics of the bone metabolic microenvironment The bone metabolism-related gene sets were obtained from the GSEA database ( http://www.gsea-msigbd .org/gsea/index.jsp) and were related to bone formation and bone resorption, such as bone remodeling, ossification, and multiple cellular processes of osteoclasts and osteoblasts ( Supplementary Table S1 ).

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