Barely Significant
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Three dimensional quantitative study of soft tissue changes in nasolabial folds after orthodontic treatment in female adults.

BMC Oral Health · 2023 · PMC9854211 · PMID 36658527

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a positive trendno p-value reported
After orthodontic treatment in the non-extraction group, the left and right corners of the mouth showed a positive trend, showing outward protrusion (cheilion left (ChL) = 0.42 mm, cheilion right (ChR) = 0.42 mm).

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a negative trendno p-value reported
The present study found that no matter whether a tooth was extracted, the NLFs had a negative trend after orthodontic treatment, and it was more obvious in the extraction group than in the non-extraction group, which may be due to the retraction of anterior teeth in the extraction group.

also in 4,201 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.