Predicting Microenvironment in CXCR4- and FAP-Positive Solid Tumors-A Pan-Cancer Machine Learning Workflow for Theranostic Target Structures.

Potentially due to low sample numbers available, upregulation of CTLA4 did not reach statistical significance.

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In line with StringDB findings, the results confirm a highly significant role for immune-related functions ( Figure 1 c)—with “lymphocyte activation” (GO:0046649), “adaptive immune response” (GO:0002250), and “B cell activation” (GO:0042113) being top predicted pathways ( p < 10 −20 ).

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