Who Knew? Dopamine Transporter Activity Is Critical in Innate and Adaptive Immune Responses.

In the DAT −/− mice, we found a significant increase in splenic dopamine ( p < 0.05, n = 4) but no significant change in norepinephrine, 5-HT, or their metabolites ( Figure 2 ), whereas in the thymus of DAT −/− mice there is a strong trend ( p < 0.052, n = 4) for increased NE, but no significant change in the other two monoamines or their metabolites ( Figure 2 ).

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