Barely Significant
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Real-Life Effectivity of Dose Intensity Reduction of First-Line mFOLFIRI-Based Treatment of Metastatic Colorectal Cancers: Sometimes Less Is More.

Curr Oncol · 2023 · PMC9857654 · PMID 36661718

Europe PMCDOI
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0.0001
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0.0001
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nearly significantp < 0.0001actually significant
In this group, mToT, mPFS, and mOS were 151, 199, and 578 days, respectively, compared to 258, 322, and 748 days in the RDI below 85%, respectively; these differences were significant or nearly significant in all studied endpoints ( p < 0.0001; 1 yr ToT OR 0.20 (95% CI: 0.12–0.34), p = 0.0002; 1 yr PFS OR 0.38 (95% CI: 0.26–0.56), and p = 0.0728; 2 yrs OS OR 0.58 (95% CI: 0.39–0.85), respectively).

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