Branched-Chain Amino Acids and Di-Alanine Supplementation in Aged Mice: A Translational Study on Sarcopenia.

A trend towards reduction in SOL muscle echodensity was observed in AGED mice treated with each formulation ( Figure 2 B, left); a significant reduction was found in GC muscles for mice treated with BCAAs, either alone or plus 2ALA, and a decreasing trend was observed in those treated with BCAAs + Di-ALA ( Figure 2 B, right).

also in 47,180 other papers

Notably, all formulations exerted a protective effect on SOL muscle force in AGED mice, with an increasing trend in sPtw (R.S.: 20–25%), paralleled by a significant increase in sP0 and by higher tetanus–frequency curves, with a statistically significant difference vs. untreated mice from the frequency of 40Hz onwards ( Figure 4 A–C).

also in 63,971 other papers

Notably, torque–frequency curves from all AGED cohorts, overlapping at T0 ( Figure 1 C), at T12 showed a trend towards increasing in mice treated with BCAAs + Di-ALA and, to a lesser extent, in those treated with BCAAs + 2ALA, with the R.S. towards ADULT values ranging between 20% and 108% at each frequency ( Figure 1 D).

also in 53,322 other papers