A cVLP-Based Vaccine Displaying Full-Length PCSK9 Elicits a Higher Reduction in Plasma PCSK9 Than Similar Peptide-Based cVLP Vaccines.

Vaccines (Basel) · 2022 · PMC9864010 · PMID 36679847

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a clear trendno p-value reported

Although, there was no statistically significant difference between the total PCSK9 level in pre-vaccination (pre-bleed) plasma and plasma obtained after immunization with either of the cVLP-PCSK9 vaccines, there was a clear trend that PCSK9 levels were higher in mice vaccinated with either of the peptide-based PCSK9 cVLP vaccines ( Figure 5 C).

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