Reverse Remodeling and Functional Improvement of Left Ventricle in Patients with Chronic Heart Failure Treated with Sacubitril/Valsartan: Comparison between Non-Ischemic and Ischemic Etiology.

J Clin Med · 2023 · PMC9864277 · PMID 36675549

Europe PMC DOI

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0.0200

closest p · 0.4× alpha

0.0200

boldest claim

The sentences

a favorable trendp = 0.02actually significant

Even the combined-endpoint favorable ventricular remodeling associated with functional improvement ( Figure 2 , Table 4 ) showed a favorable trend (log rank test p = 0.02) in non-ischemic patients, not reaching the statistical significance after adjusting for age and sex (HR: 0.17; 95% CI: 0.02–1.49; p = 0.109).

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showed a trendno p-value reported

Our data also showed a trend towards a clinically relevant reverse ventricular remodeling (>10% reduction in baseline EDV) in non-ischemic patients compared to ischemic patients, which did not reach the statistical significance (HR 1.3, 95% CI 0.61–2.75, p = 0.496.

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