Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis.

An impaired Th17 immune response was seen with reduced MPO specific splenocyte IL-17A production in mice receiving TLR9 stimulated MPO pulsed DEC205 −/− dendritic cells compared to those receiving WT dendritic cells ( Figure 7 A), although this did not reach statistical significance.

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