Polyploid/Multinucleated Giant and Slow-Cycling Cancer Cell Enrichment in Response to X-ray Irradiation of Human Glioblastoma Multiforme Cells Differing in Radioresistance and TP53/PTEN Status.

In the bulk population of LN-229 cells, IR significantly decreased the SA-β-Gal + fraction by 6-fold at 2 Gy, considering that this fraction increased up to 53% at 4 and 6 Gy, albeit it did not reach statistical significance over non-irradiated cells ( Figure 7 h).

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