Pan-cancer analysis of tissue and single-cell HIF-pathway activation using a conserved gene signature.

The total number of binding sites identified in each cell line ranged from 388 (RCC4 cells) to 1,269 (HCT116 cells) ( Figure 1 D), and although this broadly reflected the number of upregulated genes in each cell line (r = 0.74), with only 6 cell lines, the association did not reach statistical significance (p = 0.09).

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For both cell populations, several canonical HIF target genes showed highly significant correlation with the HIF metagene, including GAPDH ( Figures 6 C and 6D).

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