Barely Significant
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Neuropathology-Independent Association Between <i>APOE</i> Genotype and Cognitive Decline Rate in the Normal Aging-Early Alzheimer Continuum.

Neurol Genet · 2023 · PMC9869750 · PMID 36698453

Europe PMCDOI
1
hedged sentence
0.0770
closest p · 1.5× alpha
0.0770
boldest claim

The sentences

only marginally significantp = 0.077so close (0.05 < p ≤ 0.1)
Last, the executive domain declined significantly faster in APOE ε4 carriers than APOE ε3 homozygotes when adjusting for age, sex, and education (model 1, p = 0.028); however, this difference was only marginally significant when further adjusting by the CERAD NP score and Braak NFT stage (model 2, p = 0.077, 95% CI [−0.041 to 0.002]) and lost statistical significance when further adjusting by comorbid pathologies and the effect of ADNC on the slope (model 3, p = 0.135, 95% CI [−0.041 to 0.006]) likely due to insufficient power and the compounding effect of comorbid pathologies on executive function.

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