The gene expression analysis showed a trend of higher relative expression levels (REL) in OA iACs compared to TC28a2 line for the early chondrogenic marker Sex Determining Region Y (SRY)-Box 9 (SOX9) (17.33 (SE 2.21) and 1.00 (SE 1.64), respectively), and the late chondrogenic markers type 2 collagen alpha chain 1 (COL1A2) (2.55 (SE 0.01) and 1.00 (SE 0.50), respectively) and aggrecan (ACAN) (199.12 (SE 31.05) and 1.00 (SE 0.66), respectively).
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Generation of human immortalized chondrocytes from osteoarthritic and healthy cartilage : a new tool for cartilage pathophysiology studies.
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