Effect of BRCA1/2 Mutational Status on Survival Outcomes According to Secondary Cytoreductive Surgery and Maintenance Therapy in Platinum-Sensitive Relapsed Ovarian Cancer: A Real-World Evidence Study.

Cancer Res Treat · 2023 · PMC9873317 · PMID 35879854

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

marginal significancep=0.054so close (0.05 < p ≤ 0.1)

In the BRCA mutation group, PARPi users had better PFS than those who did not receive any maintenance therapy with marginal significance (median, 21.8 vs. 19.7 months; p=0.054), whereas BEV users did not (p=0.578).

also in 5,069 other papers

showed a trendno p-value reported

Furthermore, patients with BRCA1/2 mutations who underwent secondary CRS showed a trend of improved PFS when PARPi maintenance was administered.

also in 53,322 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.