Genetic deficiency and pharmacological modulation of RORα regulate laser-induced choroidal neovascularization.

Aging (Albany NY) · 2023 · PMC9876633 · PMID 36626253

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Choroidal explants treated with RORα modulators showed results consistent with Rora sg/sg mice, where choroidal explants treated with SR3335 to inhibit RORα revealed significantly larger (~60%) sprouting areas compared with the vehicle controls, and RORα activation with SR1078 treatment showed a trend of reduced sprouting ability ex vivo ( Figure 4D , 4E ).

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