The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis.

Cell Mol Gastroenterol Hepatol · 2023 · PMC9883297 · PMID 36309199

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did not reach statistical significanceno p-value reported

Activation of the PXR in the healing colon was accompanied by decreased expression of collagen, type I, alpha 1 ( Col1a1 ) and collagen, type I, alpha 2 ( Col1a2 ), as well as an apparent decrease in collagen, type I, alpha 3 ( Col3a1 ) expression that did not reach statistical significance ( Figure 5 G ).

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