near statistical significanceP = 0.0767
The HER2-positive cohort was subdivided into low- and high-NRG1 groups based on their initial label, and subjected to Kaplan–Meier survival analysis, which revealed that NRG1 expression significantly impacted DFI, with PFI reaching near statistical significance ( P = 0.0767), where the high-NRG1 group exhibited worse prognosis (Fig. 6f, g ).