Impact of SIV infection on mycobacterial lipid-reactive T cell responses in Bacillus Calmette-Guérin (BCG) inoculated macaques.

Notably, the increase in CD127 + γδ Tcell frequencies was highly significant in BAL at d1 (P<0.001) and 1-week (P=0.001) that returned to baseline by 3-week time-point, when BCG was likely cleared as no live bacteria was recovered from BAL fluid at that time.

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Further, expression of the Th1 marker, CXCR3, on blood γδ T cells, NKT cells, and CD8T cells showed a trend of early increase that was significant at week-3 post-BCG ( Figure 4C ).

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