Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis.

Nat Cancer · 2023 · PMC9886551 · PMID 36585450

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did not reach statistical significanceno p-value reported

TP53 and FLG genes were more frequently mutated in metastases than in primary tumors (66% versus 33% ( P = 0.006) and 28% versus 3% ( P = 0.003), respectively); however, this finding did not reach statistical significance after false discovery rate (FDR) adjustment.

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