Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma.

For individuals with hematologic malignancies, we observed a 20% increase in antibody avidity from visit 2 to visit 3, a significant increase of 16% from visit 3 to visit 4 and a highly significant increase from visit 2 to visit 4 (Fig. 1d ).

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Stimulation with the Delta peptide pools (S1 and S2) generally elicited a marginally higher T cell response than the Omicron (BA.1) peptide pools (S1 and S2) at visits 2 and 4, although these differences did not reach statistical significance (Extended Data Fig. 7a ).

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When analyzing T cell responses to Delta and Omicron (BA.1) VoCs between visit 3 and visit 4 in a combined fashion, a positive trend of the booster vaccination was observed (Extended Data Fig. 7b ).

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