Consistent with this background, our VBM results in adult female MIS offspring showed significant enlargement in the lateral and fourth ventricles, as well as a widespread reduction in several cortical regions, and an almost significant reduction in the prefrontal cortex, according to the ROI analysis.
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The Poly I:C maternal immune stimulation model shows unique patterns of brain metabolism, morphometry, and plasticity in female rats.
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Of importance, while these deficits were more pronounced in females, these neuroplasticity markers were also reduced in MIS males, although the differences did not reach statistical significance.