Ras/MAPK signalling intensity defines subclonal fitness in a mouse model of hepatocellular carcinoma.

Interestingly, while difference in the NK cell content in the primary and peritoneal tumours did not reach statistical significance in the deconvolution of stromal cells RNAseq ( Figure 4A ), immunofluorescence staining revealed distinct distribution of these cells: whereas NK infiltrate the hepatic tumours, they apparently tend to remain in the periphery of the peritoneal ones ( Figure 5—figure supplement 1 ).

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