IFNα and 5-Aza-2'-deoxycytidine combined with a dendritic-cell targeting DNA vaccine alter tumor immune cell infiltration in the B16F10 melanoma model.

Correlation between XCL1 expression and the presence of CD8+ DCs was also highly significant (p = 0.0055, R2 = 0.443) ( Figure 3E ).

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Figure 5A shows the representative gating strategy used to stratify CD8+ T cells, and total CD8+ T cells were significantly enriched in the combination group compared to IFN + 5Aza ( Figure 5C , p = 0.0003) and trending towards significance in vaccine alone (p=0.1207).

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