Mendelian randomisation study of body composition and depression in people of East Asian ancestry highlights potential setting-specific causality.

Further, after considering Bonferroni corrected significance ( P < 0.01), our one-sample results of BMI to depressive symptoms in some of our sub-analyses remained only nominally significant ( P < 0.05).

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Further, within China, different effect estimates were observed between people dwelling in urban versus rural areas, with strongly consistent inverse associations between BMI and depressive symptoms in rural regions, but an overall trend in the opposite direction in urban regions, driven by females.

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