High levels of kappa free light chain synthesis predict cognitive decline in relapsing-remitting multiple sclerosis.

Sex, MRI Gd+ lesions, evidence of disease acitivity (EDA)-3 (clinical relapses; confirmed disability worsening within 6 months, and new T1 gadolinium-enhanced lesions/new/newly enlarging T2W lesions) during the follow-up period ( 39 ), and treatment strategy (first-line therapy from start, second-line therapy from start, and escalation from first- to second-line during follow-up) did not reach statistical significance but were included in the models as they are known potential confounders ( 12 , 40 , 41 ).

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