Dynamic network biomarker identifies cdkn1a-mediated bone mineralization in the triggering phase of osteoporosis.

Exp Mol Med · 2023 · PMC9898265 · PMID 36599933

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For gene expression analysis, zebrafish larvae treated with DEX showed a trend toward a reduction in the expression of osteoblast-related genes ( runx2b, sp7, col2a1a , and sparc ) and an increase in the expression of osteoclast-related genes (mmp9 and mmp13 ) compared with those of the corresponding control group (Fig. 8e ).

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