Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis.

Exp Mol Med · 2023 · PMC9898548 · PMID 36635431

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

very close to significancep = 0.051so close (0.05 < p ≤ 0.1)

In contrast, constant darkness (107 ± 12) and melatonin (285 ± 65) caused an insignificant reduction in total Olig2+ oligodendroglia compared to that in the vehicle group (367 ± 105), and the difference induced by constant darkness was very close to significance ( p = 0.051).

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did not reach statistical significanceno p-value reported

However, this decrease in apoptosis did not reach statistical significance, possibly because of ongoing apoptosis due to the CPZ diet.

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