Immunophenotypically, the Npm1 cA/+ + Meis1 leukemic cells showed a trend toward higher Gr1 + , Mac1 + , and cKit + single-positive cells and lower Gr1 + Mac1 + cells ( supplemental Figure 1 D).
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Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice.
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