Hyperphosphorylation of hepatic proteome characterizes nonalcoholic fatty liver disease in S-adenosylmethionine deficiency.

To date, SAMe administration in human liver disease has had mixed results but has shown benefit in intrahepatic cholestasis and a near-significant benefit in alcoholic liver disease. 54 With the ability to accurately subtype human disease via non-invasive serum metabolomic and lipidomic measurements, 8 the use of SAMe in the patients with M-subtype NAFLD warrants further study.

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