Relationship of prefrontal brain lateralization to optimal cognitive function differs with age.

There, greater left-lateralization was significantly related to higher fluid ability in middle-aged adults ( β = 0.17, p = .004), bilaterality showed a trend with higher performance in older adults ( β = −.07, p = .079), and laterality was unrelated to performance in younger adults ( β = 0.11, p = .119).

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A key difference between the categorical and continuous age models is that left-lateralization was related to better fluid ability throughout young adulthood in the continuous age models, whereas this effect did not quite reach significance for younger adults in the categorical age model.

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