Common and rare variant associations with latent traits underlying depression, bipolar disorder, and schizophrenia.

Genetic correlations between each pair of traits were moderate in magnitude and were all highly significant ( p < 9.14 × 10 −14 for Levene’s test for variance heterogeneity; Tables 1 and S22 ), indicating that the continua of latent traits estimated from the population in this study shared genetic contribution with phenotypes used in case-control analyses.

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This SNP was in linkage disequilibrium with two other SNPs that were nominally significant rs78201023 (MAF = 0.0393, p = 4.01 × 10 −8 , D ’ = 0.897) and rs77512118 (MAF = 0.0372, p = 1.37 × 10 −6 , D ’ = 0.908).

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