Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health.

This percentage appears somewhat smaller than the 59% estimated relative rescue of Purkinje cell loss by DR for full-body Ercc1 Δ/− mice, examined at the age of 16 weeks, a few weeks before the progeroid mutants become moribund ( Figure 3A ; Birkisdottir et al., 2021 ), albeit the difference did not reach statistical significance ( p = 0.289 and 0.188 for 26 and 40 weeks respectively).

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