Impact of aging on meningeal gene expression.

Fluids Barriers CNS · 2023 · PMC9903605 · PMID 36747230

Europe PMC DOI

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a clear trendno p-value reported

However, in IPA a clear trend towards altered activity of these cells is apparent.

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borderline significanceno p-value reported

Interestingly, expression of most collagen genes seemed to be affected by aging with borderline significance, further suggesting an impact on the collagenous ECM of aged meninges.

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highly significantno p-value reported

In this context, the highly significant increase of Trem2 expression during aging is of special interest.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.