LAG-3⁺ tumor-infiltrating lymphocytes ameliorates overall survival in triple-negative breast cancer patients.

In addition, we further performed subgroup analyses according to the detection methods for LAG-3 + lymphocytes in TNBC and Her2-positive BC and noted that LAG-3 + lymphocyte infiltration was remarkably associated with prolonged OS in Her2-positive BC (HR = 0.43, 95% CI 0.23 to 0.83, P = 0.012), whereas it only showed a trend for improved OS in TNBC (HR = 0.93, 95% CI 0.85 to 1.01, P = 0.094) patients when such subset was measured by immunohistochemistry (IHC) ( Figure 3 ).

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