Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model.

There was also a trend towards more NOTCH3 ECD deposits inside or in close vicinity to microglia in vaccinated TgN3R182C 150 mice compared with control or sham‐vaccinated TgN3R182C 150 mice, although the difference did not reach statistical significance (Fig 7C and D ).

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