Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.

Liver expressions of IL-1β were significantly increased in WT mice upon HFD-feeding but the trending increase in IL-1β concentrations did not reach statistical significance in Casp11 –/– mice fed with HFD compared to Casp11 –/– mice fed with NCD ( Figure 4B ), suggesting that although caspase-1, other caspases ( 110 ), and neutrophil elastase ( 111 ) that are also capable of cleaving pro-IL1β are not deficient, HFD feeding induced IL-1β generation is mostly attributed by caspase-11 function.

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