FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.

However, the T-αFGL2 cells showed a trend toward enrichment in core T RM genes when compared with T-Ctr cells (Supplementary Fig. 8f , NES = 1.23, P = 0.107), suggesting that T-αFGL2 treatment does not directly transform regular T cells into brain tumor–specific T RM cells.

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