Novel TLR7/8 agonists promote activation of HIV-1 latent reservoirs and human T and NK cells.

Interestingly, while no substantial differences were found for most of the cytokines tested, a clear trend of higher levels of IFN-α2 and IFN-γ in healthy individuals than in the HIV-1 infected indicates distinct differences in host innate immune responses between the two groups of individuals toward the tested agonists.

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