Caspase-11 contributes to site-1 protease cleavage and SREBP1 activation in the inflammatory response of macrophages.

Moreover, LPS increased Srefb1a expression in WT BMDMs, as previously reported ( 33 ), while Casp4 deletion tended to decrease the upregulation of Srebf1a expression induced by LPS, though the difference did not reach statistical significance ( P = 0.0625) ( Supplemental Figure 2 ).

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