Doxycycline-Induced Changes in Circulating MMP or TIMP2 Levels Are Not Associated with Skeletal-Related Event-Free or Overall Survival in Patients with Bone Metastases from Breast Cancer.

Cancers (Basel) · 2023 · PMC9913061 · PMID 36765529

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did not reach statistical significanceno p-value reported

Although trends for baseline MMP2 and TIMP2 levels and change in MMP2 levels from baseline to week 8 with SRE-free survival were observed, these did not reach statistical significance ( Table 5 ).

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